GLP-1R Products

Antibodies
GLP-1R Antibody
GLP-1R Antibody
NBP1-97308
Species: Hu, Mu, Rt
Applications: WB, Simple Western, DB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
GLP-1R Antibody (419208) [Unc ...
GLP-1R Antibody (419208) [Unconjug...
MAB28141
Species: Hu
Applications: IHC
Host: Mouse Monoclonal
Lysates
GLP-1R Overexpression Lysate ...
GLP-1R Overexpression Lysate (Native)
NBP2-04215
Applications: WB
Proteins
GLP-1R Peptide
GLP-1R Peptide
NBP1-97308PEP
Species: Hu
GLP-1R Peptide
GLP-1R Peptide
NLS1205PEP
Species: Hu
RNAi
GLP-1R RNAi
GLP-1R RNAi
H00002740-R02
Species: Hu

Description

GLP1R, a Glucagon Receptor, has been suggested to affect the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. Glucagon-like peptide 1 is an incretin hormone produced by enteroendocrine L-cells in the intestinal mucosa. The hormone is released in response to food intake and plays an important role in maintaining blood glucose homeostasis. Stimulation of the GLP-1R by endogenous hormone induces multiple complementary mechanisms, which together result in a lowering of circulating blood glucose levels. These mechanisms include receptor-mediated enhancement of glucose-induced insulin secretion from pancreatic -cells, inhibition of gastric emptying with a delay in the gastrointestinal resorption of nutrients, inhibition of glucagon secretion, and inhibition of food intake. Desensitization of GLP1R on pancreatic beta-cells is one of the causes of non insulin-dependent diabetes mellitus (NIDDM). GLP1R knockout mice are viable, develop normally, but exhibit increased levels of blood glucose following oral glucose challenge in association with diminished levels of circulating insulin. Recently it has been shown that overexpression of glucagon-like peptide-1 receptor improves learning in rats (During et al. 2003). GLP1R has been reported in pancreas, brain, heart, kidney, lung, and stomach. ESTs have been isolated from kidney and skin libraries.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 2740
Alternate Names
  • MGC138331
  • GLP-1 receptor
  • GLP-1R
  • GLP-1-R
  • glucagon-like peptide 1 receptor

Research Areas for GLP-1R

Find related products by research area and learn more about each of the different research areas below.

Cancer
GPCR
Lipid and Metabolism
Signal Transduction

PTMs for GLP-1R

Learn more about PTMs related to GLP-1R.

Phosphorylation
Cleavage
Methylation

Bioinformatics Tool for GLP-1R

Discover related pathways, diseases and genes to GLP-1R. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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