GKAP/DLGAP1 Antibody (S127-31) [HRP]

Product Discontinued

GKAP/DLGAP1 Antibody (S127-31) [HRP] Summary

• Immunogen: Fusion protein amino acids 772-992 (C-terminus) of rat SAPAP1
• Localization: Cell Membrane , Cell Junction , Synapse , Postsynaptic Cell Membrane , Postsynaptic Density
• Specificity: Detects approx. 120kDa (SAPAP2), approx. 110kDa (SAPAP1/3/4). It does cross-react with other SAPAPs .
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: DLGAP1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 24277719).

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein G purified

Alternate Names for GKAP/DLGAP1 Antibody (S127-31) [HRP]

• DAP1
• DAP-1-ALPHA
• DAP-1DAP-1-BETA
• discs, large (Drosophila) homolog-associated protein 1
• disks large-associated protein 1
• DLGAP1
• GKAP
• GKAPMGC88156
• hGKAP
• PSD-95/SAP90 binding protein 1
• PSD-95/SAP90-binding protein 1
• SAP90/PSD-95-associated protein 1
• SAPAP1
• SAPAP1Guanylate kinase-associated protein

Background

Members of the postsynaptic density-95 (PSD-95)/SAP90 family of membraneassociated guanylate kinase (MAGUK) proteins function as multimodular scaffolds that organize protein-signaling complexes at neuronal synapses. PSD-95/SAP90 binds guanylate kinase-associated protein (GKAP), also designated GK domain-binding protein, DAP-1-alpha, DAP-1-beta, PSD-95 binding protein, PSD-95/SAP90 associated protein, or SAPAP1, through the guanylate kinase domain. SAPAP1 is expressed widely in neurons of the cortex and hippocampus and in the Purkinje and granule cells of the cerebellum. N-terminal splice variants of SAPAP1 are expressed as 95 and 130 kDa proteins. SAPAP1 is localized specifically in the PSD of glutamatergic synapses, consistent with its direct interaction with PSD-95 family proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DLGAP1
• Entrez:
  • 9229(Human)
  • 224997(Mouse)
  • 65040(Rat)
• Uniprot:
  • O14490(Human)
  • Q9D415(Mouse)
  • P97836(Rat)