GFER/ALR Antibody (829812) [Alexa Fluor® 350]

• Applications: WB, IHC
• Clone: 829812
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

GFER/ALR Antibody (829812) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human GFER/ALR
  Arg82-Asp205
  Accession # P55789
• Specificity: Detects human GFER/ALR in ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

GFER, also known as Augmenter of Liver Regeneration (ALR) and Hepatopoietin, is an approximately 30 kDa mitochondrial sulfhydryl oxidase that plays a role in protein disulfide bond formation. Alternative splicing of human GFER generates a 15 kDa secreted isoform that lacks the 80 N-terminal amino acids. Within aa 82‑205, human GFER shares approximately 86% aa sequence identity with mouse and rat GFER. GFER protects hepatocytes from toxin-induced damage, promotes hepatic regeneration, and inhibits the metastasis of hepatocellular carcinoma. It also restricts the proliferation of pluripotent and hematopoietic stem cells and maintains mitochondrial integrity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.