Gelsolin/GSN Native Protein

Product Discontinued

Gelsolin/GSN Native Protein Summary

• Description: Native bovine gelsolin.
  
  

  Source: Bovine plasma

  Amino Acid Sequence: UniProt Q3SX14

• Source: Bovine Plasma
• Protein/Peptide Type: Native Protein
• Gene: GSN
• Purity: >95%, by SDS-PAGE

Applications/Dilutions

• Dilutions:
  • Functional

Packaging, Storage & Formulations

• Storage: Store at 4C. After reconstitution store at -20C.
• Buffer: TBS, EGTA
• Concentration: LYOPH
• Purity: >95%, by SDS-PAGE
• Reconstitution Instructions: Use sterile distilled water to give a concentrated stock solution of 1 mg/ml.

Alternate Names for Gelsolin/GSN Native Protein

• Actin-depolymerizing factor
• ADF
• AGEL
• Brevin
• DKFZp313L0718
• gelsolin (amyloidosis, Finnish type)
• Gelsolin
• GSN

Background

Gelsolin is a calcium regulated actin binding protein. Gelsolin is a regulator of actin filament assembly and disassembly and consists of six homologous subdomains (S1-S6). When C-terminal tail (S6) is bound to calcium ion, it straightens and exposes actin binding sites located on S2s helices, leading to Gelsolin actin-serving activity (1). Gelsolin is inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2), where PIP2 will bind to S1, S2, and S3 sites. Gelsolin is involved in podosome formation and has been linked to inhibition of apoptosis by preventing release of cytochrome C (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: GSN