Gelsolin/GSN Products

Description

Gelsolin is a calcium regulated actin binding protein. Gelsolin is a regulator of actin filament assembly and disassembly and consists of six homologous subdomains (S1-S6). When C-terminal tail (S6) is bound to calcium ion, it straightens and exposes actin binding sites located on S2s helices, leading to Gelsolin actin-serving activity (1). Gelsolin is inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2), where PIP2 will bind to S1, S2, and S3 sites. Gelsolin is involved in podosome formation and has been linked to inhibition of apoptosis by preventing release of cytochrome C (2).

Bioinformatics

Product By Gene ID	2934
Alternate Names	Actin-depolymerizing factor ADF AGEL Brevin DKFZp313L0718 gelsolin (amyloidosis, Finnish type) Gelsolin GSN

Research Areas for Gelsolin/GSN

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Cellular Markers
Tumor Suppressors