GBL Antibody

Images

 
Western Blot: GBL Antibody [NBP1-77213] - Analysis of G bL in human brain cell lysate with G bL antibody using this antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry-Paraffin: GBL Antibody [NBP1-77213] - Mouse brain tissue with G protein beta subunit like antibody at 10 ug/ml.
Immunofluorescence: GBL Antibody [NBP1-77213] - Immunofluorescence of GBL in Mouse Brain cells with GBL antibody at 10 ug/mL.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P, ICC, IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

GBL Antibody Summary

Immunogen
Antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human GbL. The immunogen is located within the first 50 amino acids of GBL.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MLST8
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 10 ug/mL
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunocytochemistry
  • Immunofluorescence 10 ug/ml
Application Notes
GbL antibody can be used for the detection of GbL by Western blot at 1 mg/ml.
Control Peptide
GBL Peptide (NBP1-77213PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GBL Antibody

  • G protein beta subunit-like
  • gable
  • GbetaL
  • GBL
  • GBLPop3
  • Lst8
  • LST8MGC111011
  • Mammalian lethal with SEC13 protein 8
  • mLST8
  • MTOR associated protein, LST8 homolog (S. cerevisiae)
  • POP3
  • Protein GbetaL
  • target of rapamycin complex subunit LST8
  • TORC subunit LST8
  • WAT1

Background

GbetaL (G protein beta protein subunit-like) is a member of a signaling pathway that regulates mammalian cell growth in response to the presence of nutrients and growth factors. It binds to the kinase domain of TOR (Target of rapamycin, also known as mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation. TOR is normally associated with GbetaL and an additional regulatory protein RAPTOR, allowing TOR to control protein biosynthesis. The binding of GbetaL to TOR stimulates TOR's kinase activity towards downstream proteins such as RPS6K (ribosomal protein S6 kinase) and the translation factor 4E-BP1 which leads to increased protein translation and cell growth.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol MLST8
Entrez
Uniprot