WB: Approx. 65 kDa band observed in human brain (cerebral cortex) lysates (calculated MW of 66.9 kDa band according to NP_000808.2). IHC-F usage has been reported in scientific literature (PMID: 24291518), however, results may vary from lot to lot. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
67 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publication using NBP1-06989 in the following applications:
Predicted cross-reactivity based on sequence identity: Rat, Canine, Bovine, Porcine. Mouse reactivity reported in scientific literature (PMID: 24291518)
Alternate Names for GAD1/GAD67 Antibody
glutamate decarboxylase 1 (brain, 67kDa)
Glutamate decarboxylase 67 kDa isoform
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.