GABA-B R1 Antibody

Product Discontinued

GABA-B R1 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 870-913 of Human GABAB R1.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GABBR1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000
• Theoretical MW: 110 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for GABA-B R1 Antibody

• FLJ92613
• GABA B R1
• GABABR1
• GABBR1
• GABBR1-3
• gamma-aminobutyric acid (GABA) B receptor, 1
• gamma-aminobutyric acid type B receptor subunit 1
• Gb1
• GPRC3A
• GPRC3Asubunit 1c
• hGB1a
• seven transmembrane helix receptor

Background

GAD-65 and GAD-67, glutamate decarboxylases of 65 kDa and 67 kDa,respectively, function to catalyze the production of GABA (gamma-aminobutyricacid). In the central nervous system GABA (gamma-aminobutyric acid)functions as the main inhibitory transmitter by increasing a Cl-conductancethat inhibits neuronal firing. GABA has been shown to activate bothionotropic (GABAA) and metabotropic (GABAB) receptors as well as a thirdclass of receptors called GABAC. Both GABAA and GABAC are ligand-gatedion channels, however, they are structurally and functionally distinct. The GABA transporters functionto terminate GABA action.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GABBR1
• Entrez:
  • 2550(Human)
  • 54393(Mouse)
  • 25450(Rat)
• Uniprot:
  • Q9UBS5(Human)