Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, Mycoplasma
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Sheep Polyclonal
Species: Rt
Applications: IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AP
Description
GABA(B) receptor 1, a GABA(B) Receptor, forms a heterodimer with GABA(B) receptor 2 to mediate the effects of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the central nervous system. Activation of this receptor leads to fast synaptic inhibition. Reduced GABA(B) receptor 1a-b expression is implicated in the pathophysiology of temporal-lobe epilepsy. In primates, GABA(B) receptors are widely distributed and are located to subserve both pre- and postsynaptic roles in controlling synaptic transmission in the primate basal ganglia. Five alternatively spliced protein isoforms of GABA(B) receptor 1 have been identified. GABA(B) receptor 1 is widely expressed, with highest levels reported in brain, and lower levels in gastrointestinal tract, kidney, and uterus. ESTs have been isolated from a wide variety of tissues, including adrenal, brain, breast, colon, embryo, eye, ganglion, head/neck, heart, heart/melanocyte/uterus, liver/spleen, lung, nerve, placenta, prostate, stomach, testis, and tonsil libraries, among others.
Bioinformatics
| Entrez |
Human
|
| Product By Gene ID |
2550 |
| Alternate Names |
- FLJ92613
- GABA B R1
- GABABR1
- GABBR1
- GABBR1-3
- gamma-aminobutyric acid (GABA) B receptor, 1
- gamma-aminobutyric acid type B receptor subunit 1
- Gb1
- GPRC3A
- GPRC3Asubunit 1c
- hGB1a
- seven transmembrane helix receptor
|
![Immunohistochemistry GABA-B R1 Antibody (751216) [Unconjugated]](http://images.novusbio.com/fullsize2/GABA_B_R1_MAB7000_Immunohistochemistry_12256.jpg)
