FYB/ADAP/SLAP130 Antibody (460114) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clone: 460114
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

FYB/ADAP/SLAP130 Antibody (460114) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human FYB/ADAP/SLAP130 in Western blots.
• Isotype: IgG3
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FYB/ADAP/SLAP130 Antibody (460114) [Alexa Fluor™ Plus 488]

• ADAP
• Adhesion and degranulation promoting adaptor protein
• adhesion and degranulation-promoting adaptor protein
• FYB
• FYB-120/130SLAP-130FYN-binding protein (FYB-120/130)
• FYN binding protein
• FYN-binding protein
• FYN-T-binding protein
• p120/p130
• PRO0823
• SLAP130
• SLP-76-associated phosphoprotein

Background

Human SH2 domain containing leukocyte protein-76-Associated Phosphoprotein of 130 kDa (SLAP130), also known as Fyb-120 and ADAP, is an 86 kDa, 783 amino acid, cytoplasmic protein that runs anomalously as a 120‑130 kDa protein in SDS-PAGE. Human SLAP130 is a hematopoietic-specific adaptor that associates with other cytoplasmic proteins such as SH2-containing Leukocyte Phosphoprotein of 76 kDa (SLP-76). Adaptors integrate signals from surface receptors and are essential components of many immune cell-signaling cascades. There is at least one known alternatively spliced SLAP130 isoform which contains an additional 46 aa. Over the region used as immunogen, SLAP130 is 66% and 76% identical to the corresponding canine and mouse proteins, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.