Frizzled-2 Antibody (RM0236-7D14)

Product Discontinued

Frizzled-2 Antibody (RM0236-7D14) Summary

• Immunogen: Mouse Frizzled 2
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Rat
• Gene: FZD2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:100-1:2000

Reactivity Notes

Mouse

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from 0.2 um filtered PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein G purified
• Reconstitution Instructions: Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Alternate Names for Frizzled-2 Antibody (RM0236-7D14)

• frizzled (Drosophila) homolog 2
• frizzled homolog 2 (Drosophila)
• Frizzled2
• Frizzled-2
• Fz2
• fz-2
• FZD2
• fzE2
• hFz2

Background

Frizzled 2 is a receptor for Wnt proteins. Most of the frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of dishevelled proteins, inhibition of GSK3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK3 kinase. Both pathways seem to involve interactions with G-proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FZD2
• Uniprot:
  • Q9JIP6()