Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC
Host: Goat Polyclonal
Species: Hu, Mu
Applications: WB, IP
Host: Rat Monoclonal
Species: Mu
Applications: WB
Host: Goat Polyclonal
Species: Hu, Mu
Applications: Binding Activity
Species: Hu
Applications: AC
Description
Frizzled 2 is a receptor for Wnt proteins. Most of the frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of dishevelled proteins, inhibition of GSK3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK3 kinase. Both pathways seem to involve interactions with G-proteins.
Bioinformatics
| Entrez |
Human
Mouse
Rat
|
| Uniprot |
Human
Human
Mouse
|
| Product By Gene ID |
2535 |
| Alternate Names |
- frizzled (Drosophila) homolog 2
- frizzled homolog 2 (Drosophila)
- frizzled-2
- Fz2
- Fz-2
- fz-2
- fzE2
- FzE2
- hFz2
|
