FRA-1/FOSL1 Antibody (496106) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: WB
• Clone: 496106
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

FRA-1/FOSL1 Antibody (496106) [Alexa Fluor® 594] Summary

• Immunogen: E. coli-derived recombinant human FRA-1
  Gly146-Ala247
  Accession # P15407
• Specificity: Detects human FRA-1 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human FRA-2 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FRA-1/FOSL1 Antibody (496106) [Alexa Fluor® 594]

• FOSL1
• FOS-like antigen 1
• FOS-like antigen-1
• fos-related antigen 1
• FRA
• FRA1
• FRA-1

Background

FRA-1 (FOSL1) is a 271 amino acid member of the leucine zipper Fos family of transcription factors. Fos family members have been associated with cellular proliferation, differentiation and transformation. In accordance with these findings, overexpression of FRA-1 correlates with a malignant phenotype in breast cancer. In lung epithelia cells, FRA-1 promotes motility, invasion, and anchorage independent growth. FRA-1 knock out mice rescued for the FRA-1 placental defect are viable but show reduced bone formation that may be due to a defect in the osteoblast differentiation. Human FRA-1 and mouse FRA-1 are 94% identical between amino acids 146-247.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.