FPR1 Antibody (350418) [FITC]

Human peripheral blood monocytes were stained with Mouse Anti-Human FPR1 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB3744F, filled histogram) or isotype control antibody (Catalog # IC003F, open histogram). View our protocol for Staining Membrane-associated Proteins.

Product Discontinued

FPR1 Antibody (350418) [FITC] Summary

• Immunogen: HEK293 human embryonic kidney cell line transfected with human FPR1
  Met1-Lys350
  Accession # NP_002020
• Specificity: Detects human FPR1. Stains human FPR1-transfected cells but not irrelevant transfectants.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: FPR1
• Purity: Protein A or G purified from hybridoma culture supernatant
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for FPR1 Antibody (350418) [FITC]

• fMet-Leu-Phe receptor
• fMLF-R
• fMLP receptor
• FMLP
• formyl peptide receptor 1
• FPR1
• FPRfMet-Leu-Phe receptor
• N-formyl peptide receptor
• N-formylpeptide chemoattractant receptor

Background

FPR1, FPRL1, and FPRL2 constitute a group of 7-transmembrane segment chemotactic receptors that are expressed on phagocytes. FPR1 binding of bacterial N‑formyl‑methionyl peptides draws neutrophils to sites of infection and promotes degranulation. Human and mouse FPR1 share 73% amino acid sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FPR1 Antibody (FAB3744F)(3)

Publications using FAB3744F

• Kwon, WY;Jung, YS;Suh, GJ;Kim, SH;Lee, A;Kim, JY;Kim, H;Park, H;Shin, J;Kim, T;Kim, KS;Itagaki, K;Hauser, CJ; Removal of circulating mitochondrial N-formyl peptides via immobilized antibody therapy restores sepsis-induced neutrophil dysfunction Journal of leukocyte biology 2024-08-06 [PMID: 39107254] (Flow Cytometry, Human)
• L Vecchi, STS Mota, MAP Zóia, IC Martins, JB de Souza, TG Santos, AO Beserra, VP de Andrade, LR Goulart, TG Araújo Interleukin-6 Signaling in Triple Negative Breast Cancer Cells Elicits the Annexin A1/Formyl Peptide Receptor 1 Axis and Affects the Tumor Microenvironment Cells, 2022-05-20;11(10):. 2022-05-20 [PMID: 35626741] (Flow Cytometry, Human)
• STS Mota, L Vecchi, DA Alves, AO Cordeiro, GS Guimarães, E Campos-Fer, YCP Maia, BC Dornelas, SM Bezerra, VP de Andrade, LR Goulart, TG Araújo Annexin A1 promotes the nuclear localization of the epidermal growth factor receptor in castration-resistant prostate cancer Int. J. Biochem. Cell Biol., 2020-08-25;127(0):105838. 2020-08-25 [PMID: 32858191] (Flow Cytometry, Human)

Bioinformatics

• Gene Symbol: FPR1
• Uniprot:
  • NP_002020()