FOLR1 Antibody (SF55 (BGN/1210/55)) - BSA Free

Product Discontinued

FOLR1 Antibody (SF55 (BGN/1210/55)) - BSA Free Summary

• Immunogen: Folate binding protein from bovine milk
• Localization: Cell Membrane; lipid-anchor; GPI-anchor. Secreted protein
• Specificity: NB100-62577 reacts with folate binding protein (FBP), a 30 kDa protein with a high affinity for folate and several reduced folic acid derivatives that mediates the intracelullar delivery of 5 methyltetrahydrofolate. Membrane bound and soluble forms of a high affinity FBP have been found in kidney, placenta, serum, milk, and several cell lines.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: FOLR1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.01% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein G purified

Alternate Names for FOLR1 Antibody (SF55 (BGN/1210/55)) - BSA Free

• Adult folate-binding protein
• FBP
• folate binding protein
• folate receptor 1 (adult)
• Folate receptor 1
• folate receptor alpha
• Folate receptor, adult
• Folbp1
• FOLR
• FOLR1
• FR-alpha
• KB cells FBP
• MOv18
• Ovarian tumor-associated antigen MOv18

Background

Folate Binding Protein, has a high affinity for folic acid and for several reduced folic acid derivatives and mediates delivery of 5 methyltetrahydrofolate to the interior of cells. Membrane bound and soluble forms of a high affinity folate binding protein have been found in kidney, placenta, serum, milk, and in several cell lines. The 2 forms have similar binding characteristics for folates, are immunologically crossreactive, and, based upon limited amino acid sequence data, are nearly identical. There may be a precursor product relationship between the membrane and soluble forms, the membrane form having additional amino acid residues and greater molecular weight. The membrane form has been shown to mediate the transport of folate in cells grown in physiologic concentrations of folate. A function for the soluble form, which is found in serum, milk, and urine, has not been identified.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FOLR1 Antibody (NB100-62577)(2)

Publications using NB100-62577

• Jones, ML Nixon, PF. Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein. J Nutr 132:2690-2694. 2002-01-01 [PMID: 12221230]
• Henderson, GB. Folate Binding Proteins. Ann Rev Nutr 10: 319-335. 1990-01-01 [PMID: 2166548]

Bioinformatics

• Gene Symbol: FOLR1
• Entrez:
  • 432398(Human)
• Uniprot:
  • P02702(Bovine)