MDA‑MB‑231 human breast cancer cell line was stained with Mouse Anti-Human FOLR1 PE‑conjugated Monoclonal Antibody (Catalog # FAB5646P, filled histogram) or isotype control antibody (Catalog # IC002P, open ...read more
Genetic Strategies: FOLR1 knockout MCF-7 human breast cancer cell line was stained with Mouse Anti-Human FOLR1 PE-conjugated Monoclonal Antibody (Catalog # FAB5646P, filled histogram) or isotype control antibody ...read more
MCF-7 human breast cancer cell line was stained with Mouse Anti-Human FOLR1 PE-conjugated Monoclonal Antibody (Catalog # FAB5646P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View ...read more
12 months from date of receipt, 2 to 8 °C as supplied.
Supplied in a saline solution containing BSA and Sodium Azide.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for FOLR1 Antibody (548908) [Phycoerythrin]
Adult folate-binding protein
folate binding protein
folate receptor 1 (adult)
Folate receptor 1
folate receptor alpha
Folate receptor, adult
KB cells FBP
Ovarian tumor-associated antigen MOv18
Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37‑42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown (1, 2). Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage (3‑6). Human FOLR1 shares 83% amino acid sequence identity with mouse and rat FOLR1. FOLR1 is predominantly expressed on epithelial cells and is dramatically up‑regulated on many carcinomas (7, 8). It is critically required during early embryogenesis as shown in knockout mice which die in utero with gross morphological defects (9). FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface (6, 10). A soluble form of FOLR1 can be proteolytically shed from the cell surface into the blood and breast milk (11).
Kelemen, L.E. (2006) Int. J. Cancer 119:243.
Fowler, B. (2001) Kidney Int. Suppl. 78:S221.
Luhrs, C.A. et al. (1989) J. Biol. Chem. 264:21446.
Lacey, S.W. et al. (1989) J. Clin. Invest. 84:715.
Elwood, P.C. (1989) J. Biol. Chem. 264:14893.
Rijnboutt, S. et al. (1996) J. Cell Biol. 132:35.
Ross, J.F. et al. (1994) Cancer 73:2432.
Parker, N. et al. (2005) Anal. Biochem. 338:284.
Piedrahita, J.A. et al. (1999) Nat. Genet. 23:228.
Paulos, C.M. et al. (2004) Mol. Pharmacol. 66:1406.
Elwood, P.C. et al. (1991) J. Biol. Chem. 26:2346.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.
Review this Product
Be the first to review our FOLR1 Antibody (548908) [Phycoerythrin] and receive a gift card or discount.
PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.