FGF-23 Antibody (283511)

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 283511
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Unconjugated
• Concentration: LYOPH

FGF-23 Antibody (283511) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse FGF-23
  Tyr25-Val251 (Arg179Gln)
  Accession # Q9EPC2
• Specificity: Detects human and mouse FGF-23 in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) FGF acidic, rhFGF basic, rhFGF-3, -4, -5, -6, -7, -9, -10, -11, -12, -13, -16, -17, -18, -19, -20, -21, recombinant mouse (rm) FGF‑8b, rmFGF‑8c, or rmFGF-15.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Gene: FGF23
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein A or G purified from hybridoma culture supernatant
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FGF-23 Antibody (283511)

• ADHR
• FGF23
• FGF-23
• fibroblast growth factor 23
• HPDR2
• HYPF
• phosphatonin
• PHPTC
• tumor-derived hypophosphatemia inducing factor
• Tumor-derived hypophosphatemia-inducing factor

Background

FGF-23 is a secreted protein primarily expressed in the brain and thymus. Mutations in FGF-23 produced by osteomalacia tumors are linked to autosomal dominant hypophosphatemic rickets and several bone structure disorders.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FGF-23 Antibody (MAB2629)(4)

Publications using MAB2629

• N Quarto, S Shailendra, NP Meyer, S Menon, A Renda, MT Longaker Twist1-Haploinsufficiency Selectively Enhances the Osteoskeletal Capacity of Mesoderm-Derived Parietal Bone Through Downregulation of Fgf23 Front Physiol, 2018;9(0):1426. 2018 [PMID: 30374308] (Western Blot, Mouse)
• ER Smith, SJ Tan, SG Holt, TD Hewitson FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts Sci Rep, 2017;7(1):3345. 2017 [PMID: 28611350] (Western Blot, Mouse)
• Xiao Z, Huang J, Cao L, Liang Y, Han X, Quarles L Osteocyte-specific deletion of Fgfr1 suppresses FGF23. PLoS ONE, 2014;9(8):e104154. 2014 [PMID: 25089825] (Western Blot, Human)
• Takaiwa M, Aya K, Miyai T Fibroblast growth factor 23 concentrations in healthy term infants during the early postpartum period. Bone, 2010;47(2):256-62. 2010 [PMID: 20641162] (Western Blot, Human)

Bioinformatics

• Gene Symbol: FGF23
• Uniprot:
  • Q9EPC2()