Ferritin Antibody (F31)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications S-ELISA
Clone
F31
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Ferritin Antibody (F31) Summary

Immunogen
This clone has been derived from hybridization of SP2/0 myeloma cells with spleen cells of Balb/c mice immunised with purified human ferritin.
Specificity
Ferritin (F31)
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
FTH1
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Sandwich ELISA 1:100-1:2000
Application Notes
Detection of human ferritin. Suggested pair for sandwich immunoassay (capture-detection): NB110-8384 - NB110-8385

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Purity
Protein G purified

Alternate Names for Ferritin Antibody (F31)

  • apoferritin
  • Cell proliferation-inducing gene 15 protein
  • Ferritin H subunit
  • ferritin heavy chain
  • Ferritin
  • ferritin, heavy polypeptide 1
  • FHC
  • FTHEC 1.16.3.1
  • FTHL6MGC104426
  • PIG15
  • placenta immunoregulatory factor
  • PLIF
  • proliferation-inducing protein 15

Background

Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and soluble form. It forms a holoenzyme of ~450 kDa, consisting of 24 subunits of two types, H (heavy; 21 kDa) and L (light; 19 kDa), and is capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiological status of the cell, the ratio of H to L subunits in ferritin can vary widely. Ferritin is found in the liver, spleen, kidney and heart, with smaller amounts being found in blood. Serum ferritin levels serve as an indicator of the amount of iron stored in the body. Serum ferritin is the most sensitive test for anaemia, and is also used as a marker for restless leg syndrome, hemochromatosis and porphyria. As ferritin is an acute-phase reactant, it is often elevated during infection. Defects in ferritin proteins are associated with several neurodegenerative diseases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Blogs on Ferritin.

Transferrin and the blood brain barrier
Transferrin, an iron binding protein that facilitates iron uptake in cells, is an integral part of a mechanism that may introduce antibody therapies to the central nervous system. Currently, the brain’s ability to take in antibody therapies i...  Read full blog post.

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Bioinformatics

Gene Symbol FTH1
Entrez