FANCC Antibody

Product Discontinued

FANCC Antibody Summary

• Immunogen: Synthetic peptide from human FANCC.
• Specificity: Amino acids 96-112 of Human FANCC.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FANCC
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:20000-1:80000
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 2.5-5 ug/ml
  • Western Blot 1:1000-1:3000

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 30213274).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20mM Potassium Phosphate (pH 7.2) and 0.15M NaCl
• Preservative: 0.01% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for FANCC Antibody

• FA Complementation Group C
• FA3
• FACC
• FACCProtein FACC
• FACFanconi anemia group C protein
• FANCC
• Fanconi anemia, complementation group C
• FLJ14675

Background

FANCC (also called Protein FACC or Fanconi Anemia Group C protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCC may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. FANCC belongs to the multi-subunit Fanconi Anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. FANCC is mainly found within the nucleus although some protein is localized in the cytoplasm. This protein is ubiquitously expressed. Defects in FANCC are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FANCC Antibody (NBP1-03280)(2)

Publications using NBP1-03280

• Huang F, Ben Aissa M, Levesque G, Carreau M. FANCC localizes with UNC5A at neurite outgrowth and promotes neuritogenesis. BMC Res Notes 2018-09-12 [PMID: 30213274] (ICC/IF, Mouse)
• Moeller BJ, Yordy JS, Williams MD et al. DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy. Clin Cancer Res. 2011-04-01 [PMID: 21349997] (IHC-P, Human)

Bioinformatics

• Gene Symbol: FANCC
• Entrez:
  • 2176(Human)
• Uniprot:
  • Q00597(Human)