Reactivity | HuSpecies Glossary |
Applications | WB, ELISA |
Clone | RFF-VIIIC/10 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | DyLight 755 |
Immunogen | Affinity purified human Factor VIII |
Specificity | This antibody recognises human Factor VIII, an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Clone RFF-VIIIC/10 recognises an epitope within the non-functional, middle domain of full-length Factor VIII. |
Isotype | IgG1 |
Clonality | Monoclonal |
Host | Mouse |
Gene | F8 |
Purity | Protein G purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Application Notes | Optimal dilution of this antibody should be experimentally determined. |
Storage | Store at 4C in the dark. |
Buffer | 50mM Sodium Borate |
Preservative | 0.05% Sodium Azide |
Purity | Protein G purified |
Secondary Antibodies |
Isotype Controls |
Alexa Fluor 350 | NBP1-41021AF350 | |
Alexa Fluor 405 | NBP1-41021AF405 | |
Alexa Fluor 488 | NBP1-41021AF488 | |
Alexa Fluor 532 | NBP1-41021AF532 | |
Alexa Fluor 594 | NBP1-41021AF594 | |
Alexa Fluor 647 | NBP1-41021AF647 | |
Alexa Fluor 700 | NBP1-41021AF700 | |
Alexa Fluor 750 | NBP1-41021AF750 | |
Biotin | NBP1-41021B | |
DyLight 350 | NBP1-41021UV | |
DyLight 405 | NBP1-41021V | |
DyLight 488 | NBP1-41021G | |
DyLight 550 | NBP1-41021R | |
DyLight 594 | NBP1-41021DL594 | |
DyLight 650 | NBP1-41021C | |
DyLight 680 | NBP1-41021FR | |
DyLight 755 | NBP1-41021IR | |
FITC | NBP1-41021F | |
HRP | NBP1-41021H |
Diseases for Factor VIII Antibody (NBP1-41021IR)Discover more about diseases related to Factor VIII Antibody (NBP1-41021IR).
| Pathways for Factor VIII Antibody (NBP1-41021IR)View related products by pathway.
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PTMs for Factor VIII Antibody (NBP1-41021IR)Learn more about PTMs related to Factor VIII Antibody (NBP1-41021IR).
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Factor VIII - a key factor in the clotting process Hemostasis, or blood clotting, follows tissue injury and involves the deployment of essential plasma procoagulants (such as prothrombin, and Factors X, IX, V, and VIII) that trigger the blood coagulation cascade. This cascade leads to the formation... Read full blog post. |
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