Ets-1 Antibody

Product Discontinued

Ets-1 Antibody Summary

• Immunogen: This antibody was generated by immunizing rabbits with synthetic peptides of human c-Ets-1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ETS1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1-2 ug/ml
• Control:

  Jurkat Whole Cell Lysate
  Ets-1 Overexpression Lysate

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 0.2 ml PBS and 0.2% Gelatin
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein G purified

Alternate Names for Ets-1 Antibody

• Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1
• ets protein
• Ets1
• Ets-1
• EWSR2
• FLJ10768
• p54
• Protein C-Ets-1
• v-ets avian erythroblastosis virus E2 oncogene homolog 1
• v-ets avian erythroblastosis virus E26 oncogene homolog 1
• v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
• v-ets

Background

Principal Names: c-Ets-1; v-ets erythroblastosis virus E26 oncogene homlog 1 (avian); ETS-1; EWSR2; p54; Official Gene Symbol: ETS1 Gene ID: 2113 (Human) Gene Map Locus: 11q23.3 (Human) ETS1, a 441 A.A protein, is a member of DNA-binding ETS protein family. It is a multifunctional protein consisting of an N-terminal pointed domain, a central transactivation domain and 2 auto inhibitory domains flanked on both sides of conserved C-terminal Ets domain. It interacts with factors including PEBP2alphaA, p300/CBP and mediates transactivation of Osteopontin, Presenilin-1, Stromelysin and Collagenase. It is activated by Ras/MAPK signaling and its expression is up-regulated in resting T-cells. Its activity is modulated by various factors including AP-1, Sp-1, c-myb and MafB. Sp100 activates ETS1 in nuclear bodies. It interacts with EAP1/Daxx and causes repression of MMP1 and BCL2 transactivation. It interacts with STAT6 and modulates Socs-1 expression induced by IL-4. It interacts with GATA3 and positively regulates Tax-1 dependant IL-5 expression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ETS1
• Entrez:
  • 2113(Human)
• Uniprot:
  • P13474(Chicken)