Epac2 Antibody

Immunohistochemistry-Paraffin: Epac2 Antibody [NBP3-12236] - Mouse Lung. 1:100 dilution in IHC blocking buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification on Leica DM4000. FFPE sections.

Immunohistochemistry-Paraffin: Epac2 Antibody [NBP3-12236] - Mouse Liver. 1:100 dilution in IHC Blocking Buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 20X magnification on Leica DM4000. FFPE section.

Immunohistochemistry-Paraffin: Epac2 Antibody [NBP3-12236] - Mouse Liver. 1:100 dilution in IHC blocking buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification on Leica DM4000. FFPE section.

• Reactivity: Hu, Mu, Rt, Eq, Rb
• Applications: WB, ELISA, ICC/IF, IHC, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

Epac2 Antibody Summary

• Description: Novus Biologicals Rabbit Epac2 Antibody (NBP3-12236) is a polyclonal antibody validated for use in IHC, WB, ELISA, ICC/IF and IP. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Synthetic peptide corresponding to amino acids 743-762 of Epac2 protein. Sequence: CPREQFDSLTPLPEQEGPT
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RAPGEF4
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000
  • Immunocytochemistry/ Immunofluorescence 1:200
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation 1:200
  • Western Blot 1:500

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary).
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Epac2 Antibody

• cAMP-GEFII
• cAMP-regulated guanine nucleotide exchange factor II
• CGEF2
• CGEF2EPAC 2
• EPAC 2
• Epac2
• Exchange factor directly activated by cAMP 2
• Exchange protein directly activated by cAMP 2
• Nbla00496
• putative protein product of Nbla00496
• Rap guanine nucleotide exchange factor (GEF) 4
• rap guanine nucleotide exchange factor 4
• RAP guanine-nucleotide-exchange factor (GEF) 4
• RAPGEF4

Background

Epac2, also known as Rap Guanine Nucleotide Exchange Factor (GEF) 4, is a guanine nucleotide exchange factor for RAP1A, RAP1B and RAP2A small GTPases. Studies have shown that EPAC2 has a significant role in the development of type 2 diabetes. EPAC2 has also been studied in relation to ataxia, neuronitis, osteoporosis and pancreatitis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RAPGEF4