DYRK2 Antibody [FITC]

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Product Details

Summary
Reactivity Hu, Ch, Mu(-), Rt(-), ZeSpecies Glossary
Applications ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
FITC

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Catalog# & Conjugate Size Price

DYRK2 Antibody [FITC] Summary

Immunogen
Synthetic peptide made to an internal portion of human DYRK2 (within residues 400-500). [Swiss-Prot# Q92630]
Localization
Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.
Predicted Species
Zebrafish (91%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DYRK2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
Application Notes
This DYRK2 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen ~60 kDa. In ICC/IF cytoplasmic staining was observed.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
60 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human and chicken. Does not react with mouse and rat. Immunogen sequence has 91% homology to Zebrafish.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for DYRK2 Antibody [FITC]

  • dual specificity tyrosine-phosphorylation-regulated kinase 2
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
  • DYRK2
  • EC 2.7.12
  • EC 2.7.12.1
  • FLJ21217
  • FLJ21365

Background

DYRK2, or dual specificity tyrosine-phosphorylation-regulated kinase 2, has a role in the regulation of cellular growth and/or development. In response to DNA damage, DYRK2 regulates p53 phosphorylation on Ser-46 to induce apoptosis. DYRK2 has been proposed to inactivate GYS1 by phosphorylation at Ser-641, and potentially a second phosphorylation site, thus regulating glycogen synthesis. DYRK2 also phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol DYRK2
Entrez