DMPK Antibody

Western Blot: DMPK Antibody [H00001760-D01P] - Analysis of DMPK expression in NIH/3T3.

Western Blot: DMPK Antibody [H00001760-D01P] - Analysis of DMPK expression in HeLa.

Western Blot: DMPK Antibody [H00001760-D01P] - Analysis of DMPK expression in PC-12.

Western Blot: DMPK Antibody [H00001760-D01P] - Analysis of DMPK expression in transfected 293T cell line by DMPK polyclonal antibody.Lane 1: DMPK transfected lysate(69.40 KDa).Lane 2: Non-transfected lysate.

Product Discontinued

DMPK Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: DMPK (NP_004400.4, 1 a.a. - 629 a.a.) full-length human protein. MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP
• Specificity: DMPK - dystrophia myotonica-protein kinase,
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DMPK
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB and also on transfected lysate in WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for DMPK Antibody

• DM1
• DM1PK
• DMK
• DMKEC 2.7.11.1
• DM-kinase
• DMmyotonin protein kinase A
• DMPK
• dystrophia myotonica-protein kinase
• MDPK
• MDPKDM protein kinase
• MT-PK
• MT-PKmyotonic dystrophy associated protein kinase
• Myotonic dystrophy protein kinase
• myotonin-protein kinase
• thymopoietin homolog

Background

The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DMPK
• Entrez:
  • 1760(Human)
• Uniprot:
  • NP_004400.4(Human)