DISP2 Antibody (758204) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: WB
• Clone: 758204
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

DISP2 Antibody (758204) [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human DISP2
  Arg192-Lys477
  Accession # A7MBM2
• Specificity: Detects human DISP2 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DISP2 Antibody (758204) [Alexa Fluor® 488]

• DISP2
• Dispatched B
• Dispatched Homolog 2 (Drosophila)
• DISPB
• HsT16908
• KIAA1742
• Protein Dispatched Homolog 2

Background

DISP2 (Dispatched Homolog 2), also known as DISPB, belongs to the dispatched family of sterol-sensing proteins.  DISP2 and the closely related DISP1 were initially identified in mice by their high homology with Dispatched, a protein required for long-range Hedgehog (Hh) signaling in Drosophila.  Like DISP1, DISP2 is a multispan (12) transmembrane protein with both cytoplasmic N- and C-terminal tails.  DISP2 contains a sterol-sensing domain (SSD) of 173 amino acids (aa), and may be involved in regulating the release of cholesterol-modified Sonic Hedgehog (Shh).  Human DISP2 is 1401 aa in length, with three predicted N-linked glycosylation sites.  Over aa 192-477, human DISP2 shares 72% and 73% aa identity with mouse and rat DISP2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.