Desmoglein-1 Antibody (129204) [Unconjugated]

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Desmoglein‑1 was detected in immersion fixed paraffin-embedded sections of human skin hyperplasia using Mouse Anti-Human Desmoglein‑1 Monoclonal Antibody (Catalog # MAB944) at 5 µg/mL for 1 hour at room ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clone
129204
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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Catalog# & Formulation Size Price

Desmoglein-1 Antibody (129204) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Desmoglein-1
Glu50-His545
Accession # Q02413
Specificity
Detects human Desmoglein-1 in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) Desmoglein-2 or rhDesmoglein-3.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
DSG1
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • Immunohistochemistry 5-25 ug/mL
Publications
Read Publication using
MAB944 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Desmoglein-1 Antibody (129204) [Unconjugated]

  • Cadherin family member 4
  • CDHF4
  • CDHF4PPKS1
  • desmoglein 1
  • Desmoglein1
  • Desmoglein-1
  • Desmosomal glycoprotein 1
  • DG1
  • DGI
  • DSG
  • DSG1
  • Pemphigus foliaceus antigen
  • SPPK1

Background

Desmoglein-1 is one of three members of the desmoglein subfamily of calcium-dependent cadherin cell adhesion molecules. Together with desmocollins, another subfamily within the cadherin superfamily, the desmoglein isoforms form the adhesive components of desmosomes, the cell-cell adhesive structures that are found in epithelial cells. Human Desmoglein-1 is a type I transmembrane glycoprotein of 1049 amino acid (aa) residues with a 23 aa signal peptide and a 26 aa propeptide. It differs from other classic cadherins by having four instead of five cadherin repeat domains in its extracellular region, and a much larger cytoplasmic region containing five desmoglein repeat domains which share homology with the cadherin repeats. Instead of having the HAV adhesion motif found in type I cadherins, Desmoglein-1 has R/YAL as the adhesion motif on its amino-terminal cadherin repeat. The cytoplasmic tail of Desmoglein-1 interacts with desmoplakins, plakoglobin and plakophilins. In turn, these proteins link the Desmoglein-1 with the intermediate filaments. Desmoglein-1 has been shown to be important in establishing cell-cell adhesion and function in the epidermis. In the autoimmune skin disease pemphigus foliaceus, autoantibodies to Desmoglein-1 can cause the loss of keratinocyte adhesion resulting in blisters.
  1. Nollet, R. et al. (2000) J. Mol. Biol. 299:551.
  2. Elias, P. et al. (2001) J. Cell Biol. 153:243.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Desmoglein-1 Antibody (MAB944)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow.


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Bioinformatics

Gene Symbol DSG1
Entrez
Uniprot