DEK Antibody (715524) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 715524
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

DEK Antibody (715524) [Alexa Fluor® 488] Summary

• Immunogen: Human embryonic kidney cell line HEK293EBNA-derived recombinant human DEK
  Ser2-Ser375
  Accession # P35659
• Specificity: Detects human DEK in direct ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DEK Antibody (715524) [Alexa Fluor® 488]

• D6S231EDEK oncogene (DNA binding)
• DEK oncogene
• DEK
• protein DEK

Background

The DEK oncogene is an approximately 45 kDa phosphoprotein with pleiotropic activities. It is a chromatin remodeling factor, a transcriptional coactivator and corepressor, a component of RNA spliceosomes, and a promoter of DNA repair during apoptosis. DEK is upregulated in many cancers and promotes epithelial cell transformation. It functions as a proinflammatory factor when secreted by activated macrophages. It is an autoantigen in juvenile arthritis and lupus and a target of chromosomal translocation with the CAN gene in acute myelogenous leukemia. DEK contains one SAP domain (aa 149-183), one nuclear localization sequence (aa 205-221), and a DNA-binding C-terminal domain (aa 321-375). Within aa 292-375, human DEK shares 95% aa sequence identity with mouse and rat DEK.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.