DARC Antibody (358307) [Alexa Fluor® 750]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
358307
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 750
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

DARC Antibody (358307) [Alexa Fluor® 750] Summary

Immunogen
HEK293 human embryonic kidney cell line transfected with human DARC
Met1-Ser336
Accession # Q16570
Specificity
Detects human DARC. Stains human DARC transfected cells but not irrelevant transfectants.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
DARC
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
0.09% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DARC Antibody (358307) [Alexa Fluor® 750]

  • ACKR1
  • CCBP1
  • CD234 antigen
  • CD234
  • DARC
  • Dfy
  • Duffy Antigen
  • Duffy antigen/chemokine receptor
  • Duffy blood group antigen
  • Duffy blood group, chemokine receptor
  • Fy Antigen
  • Fy glycoprotein
  • FYDuffy blood group
  • Glycoprotein D
  • GPD
  • GPDWBCQ1
  • GpFy
  • Plasmodium vivax receptor

Background

Duffy Antigen Receptor for Chemokines (DARC), also known as Fy glycoprotein and CD234, is a 7TM non-signaling chemokine receptor that is expressed on venular endothelial cells and erythrocytes. DARC binds and mediates the internalization of several inflammatory CC and CXC chemokines. It transports chemokines to the lumenal face of venular endothelium to promote the extravasation of leukocytes to sites of inflammation. DARC polymorphisms are important in blood transfusion compatibility and determine the susceptibility of erythrocytes to Plasmodium vivax infection. Human DARC shares 60% amino acid sequence identity with mouse DARC.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol DARC
Uniprot