DAN/NBL1 Antibody [PE]

• Reactivity: Hu
• Applications: WB, IHC, B/N
• Clonality: Polyclonal
• Host: Goat
• Conjugate: PE

DAN/NBL1 Antibody [PE] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human DAN
  Ala17-Asp180 (Ala36Arg)
  Accession # Q5U0N4
• Specificity: Detects human DAN in direct ELISAs and Western blots. In direct ELISAs, approximately 25% cross-reactivity with recombinant mouse (rm) DAN is observed and less than 1% cross-reactivity with recombinant chicken Caronte, rmGremlin, and recombinant human Cerberus 1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: NBL1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Blockade of Receptor-ligand Interaction
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Alternate Names for DAN/NBL1 Antibody [PE]

• DAN domain family member 1
• DAN
• DAND1
• MGC8972
• NBL1
• neuroblastoma suppressor of tumorigenicity 1
• neuroblastoma, suppression of tumorigenicity 1
• Protein N03
• suppression of tumorigenicity 1
• Zinc finger protein DAN

Background

NBL1 product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NBL1