Cytosolic Sulfotransferase 2B1/SULT2B1 Antibody (682516) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: IHC
• Clone: 682516
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

Cytosolic Sulfotransferase 2B1/SULT2B1 Antibody (682516) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human Cytosolic Sulfotransferase 2B1/SULT2B1
  Asp2-Ser365
  Accession # O00204
• Specificity: Detects human Cytosolic Sulfotransferase 2B1/SULT2B1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) SULT1A1, 1A3, 1B1, 1C4, 1E1, 2A1, or 4A1 is observed.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cytosolic Sulfotransferase 2B1/SULT2B1 Antibody (682516) [Alexa Fluor® 405]

• Alcohol sulfotransferase
• Cytosolic Sulfotransferase 2B1
• EC 2.8.2
• EC 2.8.2.2
• HSST2
• HSST2sulfotransferase family cytosolic 2B member 1
• Hydroxysteroid sulfotransferase 2
• ST2B1
• Sulfotransferase 2B1
• sulfotransferase family, cytosolic, 2B, member 1
• SULT2B1

Background

SULT2B1 (Sulfotransferase 2B1; also ST2B1 and alcohol sulfotransferase) is a 45-48 kDa member of the sulfotransferase 1 family of enzymes. SULT2B1 is widely expressed, being found in platelets, stratum granulosum keratinocytes, breast and prostatic epithelium, and syncytiotrophoblast cells. SULT2B1 catalyzes the sulfonation of DHEA, a precursor for sex steroids, and cholesterol, which supports stratification of the epidermis. Human SULT2B1 is 365 amino acids (aa) in length. There are PAPS binding sites between aa 70-75 and 147-155, a myristoylation motif between aa 255-259, and a Pro-rich region between aa 305-364 that may extend enzyme half-life. There is one 43 kDa splice form (ST2B1a) that shows an eight aa substitution for aa 1-23. It is expressed in fetal brain and generates pregnenolone sulfate, a steroid that modulates neurotransmitters. Full-length human SULT2B1 shares 71% aa identity with mouse SULT2B1.        

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • O00204(Human)