Cytokeratin 19 Antibody (A53-B/A2.26 + BA17) [DyLight 405]

Immunohistochemistry-Frozen: Cytokeratin 19 Antibody (A53-B/A2.26 + BA17) [DyLight 405] [NBP2-34548V] - Human breast cancer tissue stained with CK19 antibody. IHC-Fr image submitted by a verified customer review.

• Reactivity: Hu
• Applications: WB, IHC
• Clone: A53-B/A2.26 + BA17
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 405

Cytokeratin 19 Antibody (A53-B/A2.26 + BA17) [DyLight 405] Summary

• Description: This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
• Immunogen: Human breast cancer MCF-7 cells (A53-B/A2); Human mammary epithelial organoids (BA17)
• Localization: Cytoplasmic
• Marker: Pancreatic Stem Cell Marker
• Specificity: This monoclonal antibody reacts with the rod domain of human cytokeratin-19 (CK19), a polypeptide of 40kDa. CK19 is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.
• Isotype: IgG2a Lambda/IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: KRT19
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Cytokeratin 19 Antibody (A53-B/A2.26 + BA17) [DyLight 405]

• 40-kDa keratin intermediate filament
• CK19
• CK-19
• Cytokeratin 19
• EndoC
• K19
• K1CS
• keratin 19
• keratin, type I cytoskeletal 19
• keratin, type I, 40-kd
• keratin-19
• Krt19
• MGC15366

Background

Cytokeratin 19 (also known as Keratin, type I cytoskeletal 19) belongs to the keratin family which consists of fibrous proteins that make up the framework of epithelial cells. Cytokeratin 19 plays a role in the organization of myofibers. This protein is known to have interactions with ZNF638, FANCG, FAM107A, KRT15 and EXOC8. Cytokeratin 19 has been studied in relation to several disorders and diseases including chordoma, adenoma, hamartoma, adenoiditis, carcinoma, and liver disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Review for Cytokeratin 19 Antibody (NBP2-34548V) (1)

Average Rating: 5

(Based on 1 review)

We have 1 review tested in 1 species: Human.

reviewed by: Jan Martinek IHC-Fr Human 07/20/2020

Summary

• Application: Immunohistochemistry-Frozen
• Sample Tested: Breast cancer tissue
• Species: Human
• Lot: 3880-3PABX191024-071520-V

Comments

• Comments: Acetone fixation

Bioinformatics

• Gene Symbol: KRT19