Cytochrome P450 3A5 Antibody (RB15796)

Product Discontinued

Cytochrome P450 3A5 Antibody (RB15796) Summary

• Immunogen: This CYP3A5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-502 amino acids from the C-terminal region of human CYP3A5.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CYP3A5
• Purity: Ammonium sulfate precipitation

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10 - 1:50
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:10 - 1:50
  • Western Blot 1:1000
• Theoretical MW: 57.109 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 8.42 mg/ml
• Purity: Ammonium sulfate precipitation

Alternate Names for Cytochrome P450 3A5 Antibody (RB15796)

• aryl hydrocarbon hydroxylase
• CP35
• CYP3A5
• CYPIIIA5
• Cytochrome P450 3A5
• Cytochrome P450 HLp2
• cytochrome P-450
• cytochrome P450, family 3, subfamily A, polypeptide 5
• cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5
• Cytochrome P450-PCN3
• DKFZp686L16231
• EC 1.14.14.1
• flavoprotein-linked monooxygenase
• microsomal monooxygenase
• niphedipine oxidase
• P450PCN3FLJ31317
• PCN3
• xenobiotic monooxygenase

Background

CYP3A5 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CYP3A5
• Uniprot:
  • P20815(Human)