Cytochrome P450 3A5 Products

Description

This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene.

Bioinformatics

Entrez	1577 Human
Uniprot	AAH33862.1 Human
Product By Gene ID	1577
Alternate Names	aryl hydrocarbon hydroxylase CP35 CYP3A5 CYPIIIA5 Cytochrome P450 3A5 Cytochrome P450 HLp2 cytochrome P-450 cytochrome P450, family 3, subfamily A, polypeptide 5 cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5 Cytochrome P450-PCN3 DKFZp686L16231 EC 1.14.14.1 flavoprotein-linked monooxygenase microsomal monooxygenase niphedipine oxidase P450PCN3FLJ31317 PCN3 xenobiotic monooxygenase

Research Areas for Cytochrome P450 3A5

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Lipid and Metabolism