Cytochrome P450 3A4 Antibody

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Product Details

Summary
Reactivity Rt, Hu, Mk, PmSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.03 mg/ml

Order Details

Cytochrome P450 3A4 Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human CYP3A4. The exact sequence is proprietary.
Localization
Endoplasmic reticulum membrane; Microsome membrane
Predicted Species
Human (100%), Monkey (94%), Primate (99%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CYP3A4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
Theoretical MW
57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Rhesus Monkey (94%), Chimpanzee (99%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
Preservative
0.01% Thimerosal
Concentration
1.03 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Cytochrome P450 3A4 Antibody

  • Albendazole Monooxygenase
  • Albendazole Sulfoxidase
  • CP33
  • CP34
  • CYP3A
  • CYP3A3
  • CYP3A4
  • CYPIIIA3
  • CYPIIIA4
  • Cytochrome P450 3A3
  • cytochrome P450 3A4
  • Cytochrome P450 HLp
  • Cytochrome P450 NF-25
  • cytochrome P450, family 3, subfamily A, polypeptide 4
  • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
  • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
  • Cytochrome P450-PCN1
  • EC 1.14.13.32
  • EC 1.14.13.67
  • EC 1.14.13.97
  • EC 1.14.14.1
  • glucocorticoid-inducible P450
  • HLP
  • MGC126680
  • NF-25
  • Nifedipine oxidase
  • P450C3
  • P450-III, steroid inducible
  • P450PCN1
  • Quinine 3-Monooxygenase
  • Taurochenodeoxycholate 6-Alpha-Hydroxylase

Background

This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CYP3A4
Entrez
Uniprot