Cytochrome P450 3A4 Antibody (946002) [Alexa Fluor® 488]

• Applications: WB
• Clone: 946002
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

Cytochrome P450 3A4 Antibody (946002) [Alexa Fluor® 488] Summary

• Immunogen: Human CYP3A4 synthetic peptide
  Lys67-Pro80
  Accession # P08684
• Specificity: Detects human CYP3A4 in Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

CYP3A4 (cytochrome P450, subfamily 3A, polypeptide 4) belongs to the cytochrome P450 superfamily of monooxygenases that catalyze reactions involved in both drug metabolism and the synthesis of cholesterol, steroids, and other lipid components.  CYP3A4 is predominantly found in liver microsomes, but has also been detected in prostate, small and large intestine, bile duct, nasal mucosa, kidney and adrenal cortex.  It is an extremely important enzyme for drug metabolism; CYP3A4 catalyzes phase I oxidation reactions in an estimated 60% of all clinically used drugs, promoting in most cases their clearance by excretion.  CYP3A4 levels are induced by glucocorticoids and various xenobiotics, including drugs, pesticides and carcinogens.  Human CYP3A4 is a 50 kDa single-pass membrane protein, 503 amino acids in length.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.