Cysteinyl Leukotriene R2/CysLTR2 Antibody

Product Discontinued

Cysteinyl Leukotriene R2/CysLTR2 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 292-343 of Human CysLTR2.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CYSLTR2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:50-1:200
  • Western Blot 1:500-1:1000
• Application Notes: Western blot (WB) analysis of CysLT2 (H324) pAb in extracts from COLO cells.
• Theoretical MW: 40 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Cysteinyl Leukotriene R2/CysLTR2 Antibody

• CysLT(2)
• CysLT2
• CYSLT2KPG_011
• CYSLT2RHG57
• CysLTR2
• cysteinyl leukotriene CysLT2 receptor
• Cysteinyl Leukotriene R2
• cysteinyl leukotriene receptor 2
• Cysteinyl LeukotrieneR2
• G protein-coupled receptor
• G-protein coupled receptor GPCR21
• G-protein coupled receptor HG57
• HG57
• hGPCR21
• HPN321
• KPG_011

Background

Cysteinyl leukotriene (CysLTs) induce intracellular calcium mobilization through the binding of two distinct seven-transmembrane, G protein-coupled receptors, designated CysLT1 Receptor and CysLT2 Receptor, to induce potent bronchoconstriction. Airway smooth muscle and macrophages express both receptor types, and additionally monocytes and eosinophils express CysLT1 Receptor, while cardiac Purkinje cells, adrenal medulla, peripheral blood leukocytes and brain also utilize CysLT2 Receptor. The effects of the CysLT Receptors can be blocked by antagonists, indicating a therapeutic mechanism for the treatment of asthma and allergies.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CYSLTR2
• Entrez:
  • 57105(Human)