Cystatin S Antibody (201805) [Alexa Fluor® 350]

• Applications: WB, IP
• Clone: 201805
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Cystatin S Antibody (201805) [Alexa Fluor® 350] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Cystatin S
  Ser21-Ala141
  Accession # P01036
• Specificity: Detects human Cystatin S in direct ELISAs and Western blots. In direct ELISAs, 100% cross-reactivity with recombinant human (rh) Cystatin SA is observed and no cross-reactivity with rhCystatin D, E, SN, rhFetuin A, rhFetuin B, or rhHPRG (Hi
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Cystatin S is a member of family 2 of the Cystatin superfamily (1). Like Cystatins SA and SN, it is produced by the salivary gland and secreted largely in the submandibular/sublingual saliva (2). Unlike Cystatins SA and SN, Cystatin S is not a potent inhibitor of cysteine proteases such as papain and some cathepsins (3). Cystatin S is partially phosphorylated at Ser21 and Ser23 in saliva (4). The functions of Cystatin S are largely unknown. However, it is able to bind more calcium and bind more rapidly to carbonated apatite than cystatins SA or SN, indicating that Cystatin S may be involved in the mineral balance of the tooth (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.