Cystatin S Antibody (201805) [Alexa Fluor™ Plus 594]

• Clone: 201805
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 594

Cystatin S Antibody (201805) [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects human Cystatin S in direct ELISAs and Western blots. In direct ELISAs, 100% cross-reactivity with recombinant human (rh) Cystatin SA is observed and no cross-reactivity with rhCystatin D, E, SN, rhFetuin A, rhFetuin B, or rhHPRG (Histidine-Proline-Rich Glycoprotein) is observed. In Western blots, approximately 15% cross‑reactivity with rhCystatins SA and SN (under reducing conditions only) is observed and no cross‑reactivity with rhCystatin A, B, C, D, E/M, rhFetuin A, rhFetuin B, or rhHPRG is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cystatin S Antibody (201805) [Alexa Fluor™ Plus 594]

• CST4
• cystatin 4
• Cystatin S
• Cystatin-4
• cystatin-S
• cystatin-SA-III
• MGC71923
• Salivary acidic protein 1

Background

Cystatin S is a member of family 2 of the Cystatin superfamily (1). Like Cystatins SA and SN, it is produced by the salivary gland and secreted largely in the submandibular/sublingual saliva (2). Unlike Cystatins SA and SN, Cystatin S is not a potent inhibitor of cysteine proteases such as papain and some cathepsins (3). Cystatin S is partially phosphorylated at Ser21 and Ser23 in saliva (4). The functions of Cystatin S are largely unknown. However, it is able to bind more calcium and bind more rapidly to carbonated apatite than cystatins SA or SN, indicating that Cystatin S may be involved in the mineral balance of the tooth (3).

1. Abrahamson, M. (1994) Methods Enzymol. 244:685.
2. Baron, A.C. et al. (1999) Oral. Dis. 5:344.
3. Baron, A. et al. (1999) Oral Dis. 5:234.
4. Isemura, S. et al. (1991) J. Biochem. 110:648.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.