CTP synthase Antibody

Immunohistochemistry: CTP synthase Antibody [23370002] - Moderate to strong cytoplasmic immunoreactivity, occasionally combined with nuclear positivity, was observed in normal and malignant tissues. Most glandular epithelia, cells of the central nervous system and renal tubuli displayed strong cytoplasmic staining. Most cases of colo-rectal, prostate and breast cancers showed strong cytoplasmic expression. Image and statement courtesy of the Human Protein Atlas (HPA).

ELISA: CTP synthase Antibody [23370002]

Product Discontinued

CTP synthase Antibody Summary

• Immunogen: This antibody is specific for the C Terminus Region of the target protein.
• Specificity: This product is specific for Human CTPS.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CTPS1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
• Application Notes: This antibody is useful in ELISA and Immunohistochemistry-Paraffin.

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

Manufactured by SDIX's proprietary Genomic Antibody Technology™. GAT FAQs.

Alternate Names for CTP synthase Antibody

• CTP Synthase 1
• CTP synthase
• CTP synthetase 1
• CTPS1
• cytidine 5-prime triphosphate synthetase
• cytidine 5'-triphosphate synthetase
• EC 6.3.4.2
• GATD5
• IMD24
• UTP--ammonia ligase 1

Background

The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CTP synthase Antibody (23370002)(2)

Publications using 23370002

• Garrison C, Lastwika K, Zhang Y et al. Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections With Obesity J Proteome Res. 2017-01-06 [PMID: 27769113] (MiAr)
  
  Details:
  Analysis is performed on plasma proteomic data to identify how obesity can alter pathways and to highlight the risk factor for disease in subjects with a high body mass index.
• Rho JH, Lampe PD. High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays J Proteome Res. 2013-05-03 [PMID: 23541305] (MiAr)
  
  Details:
  A novel method using antibody microarrays is used to detect autoantibody-antigen complexes that can potentially be useful for detection and characterization of diseases.

Bioinformatics

• Gene Symbol: CTPS1
• Entrez:
  • 1503(Human)
• Uniprot:
  • P17812(Human)