CtIP Antibody - BSA Free

Western Blot: CtIP Antibody [NBP1-77165] - Mouse spleen tissue lysate with CtIP antibody at (A) 1 and (B) 2 ug/mL.

Immunocytochemistry/ Immunofluorescence: CtIP Antibody - BSA Free [NBP1-77165] - Immunofluorescence of CtIP in rat spleen tissue with CtIP antibody at 20 u/mL.

Immunohistochemistry: CtIP Antibody - BSA Free [NBP1-77165] - Immunohistochemistry of CtIP in rat spleen tissue with CtIP antibody at 5 ug/mL.

Product Discontinued

CtIP Antibody - BSA Free Summary

• Immunogen: Antibody was raised against a 14 amino acid synthetic peptide near the center of human RBBP8. The immunogen is located within amino acids 430 - 480 of RBBP8. Amino Acid Squence: CRTSKRKKTEEESEH
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RBBP8
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/mL
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1-2 ug/ml

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for CtIP Antibody - BSA Free

• CtBP-interacting protein
• CtIP
• DNA endonuclease RBBP8
• EC 3.1
• RBBP-8
• retinoblastoma binding protein 8
• Retinoblastoma-binding protein 8
• Retinoblastoma-interacting protein and myosin-like
• RIMSAE2
• Sporulation in the absence of SPO11 protein 2 homolog

Background

RBBP8, also known as CtBP (carboxy-terminal binding protein) interacting protein (CTIP), was characterized for its role in transcription as a cofactor for the transcriptional repressor CtBP, and also as a binding partner for other proteins including the cell cycle regulators retinoblastoma protein (Rb) and breast cancer 1 (BRCA1). It is ubiquitously expressed and localizes to the nucleus. RBBP8 is thought to modulate the functions in cell proliferation, transcriptional regulation and DNA repair. RBBP8 also plays a central role in the cell cycle checkpoint response to DNA double-stranded breaks (DSBs), with new evidence demonstrating that it controls the choice of DSB repair pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RBBP8
• Uniprot:
  • NP_976037(Human)