CRMP5 Antibody (CR-1)

Immunohistochemistry-Paraffin: CRMP5 Antibody (CR-1) [NB100-74395] - Biopsies of deparaffinized Human glioma tissue.

Immunohistochemistry-Paraffin: CRMP5 Antibody (CR-1) [NB100-74395] - Biopsies of deparaffinized Human brain tissue.

Product Discontinued

CRMP5 Antibody (CR-1) Summary

• Immunogen: CRMP5 protein purified from human brain.
• Specificity: CRMP5 (CR-1)
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Rat
• Gene: DPYSL5
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 2 - 3 ug/mL
  • Immunohistochemistry 1:2000
  • Immunohistochemistry-Frozen 1:2000
  • Immunohistochemistry-Paraffin 1:2000
  • Single Cell Western
  • Western Blot 1:1000 - 1:2000
• Application Notes: WB: Detects an approx. 62 kDa protein representing human CRMP5 from brain extract.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Ascites
• Preservative: 0.05% Sodium Azide
• Purity: Unpurified

Alternate Names for CRMP5 Antibody (CR-1)

• Collapsin response mediator protein 5
• collapsin response mediator protein-5
• CRAMCRMP3-associated molecule
• CRMP-5FLJ45383
• CRMP5UNC33-like phosphoprotein 6
• dihydropyrimidinase-like 5
• dihydropyrimidinase-related protein 5
• DRP-5
• Ulip6
• ULIP-6

Background

The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DPYSL5
• Entrez:
  • 56896(Human)
  • 65208(Rat)