CrkL Antibody (515405) [Alexa Fluor® 350]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: 515405
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

CrkL Antibody (515405) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human CrkL
  Met1-Glu303
  Accession # P46109
• Specificity: Detects human, mouse and rat CrkL in Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CrkL Antibody (515405) [Alexa Fluor® 350]

• CrkL
• crk-like protein
• pCRKL
• v-crk avian sarcoma virus CT10 oncogene homolog-like
• v-crk sarcoma virus CT10 oncogene homolog (avian)-like

Background

CrkL is a widely-expressed 39 kDa adaptor protein that belongs to the Crk protein family and is abundantly expressed in cells of hematopoietic origin. Through its SH2 and SH3 domains, CrkL initiates interactions with numerous downstream proteins such as CBL, p130Cas, Paxillin, C3G, SOS, PI3K, c-Abl and BCR/Abl. CrkL is involved in such processes as adhesion, migration and the immune response. Furthermore, this adaptor protein plays an essential role in Chronic Myelogenous Leukemia (CML) and is constitutively phosphorylated at Y207 in CML neutrophils by the BCR/Abl kinase.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.