Crk Antibody (463414) [Alexa Fluor® 750]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 463414
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

Crk Antibody (463414) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human Crk
  Gln205-Ser304
  Accession # P46108
• Specificity: Detects human Crk in direct ELISAs and human and mouse Crk in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Crk Antibody (463414) [Alexa Fluor® 750]

• adapter molecule crk
• avian sarcoma virus CT10 (v-crk) oncogene homolog
• Crk
• CRKII
• p38
• Proto-oncogene c-Crk
• v-crk avian sarcoma virus CT10 oncogene homolog
• v-crk sarcoma virus CT10 oncogene homolog (avian)

Background

Crk belongs to a family of adaptor molecules that are widely expressed in numerous tissues. It was originally isolated from a chicken tumor sample, and despite lacking enzymatic activity, this protein is involved in many signal transduction pathways leading to phosphorylation of multiple proteins. Crk forms multi protein complexes via it’s SH2 (aa 13-118) and SH3 (aa 132-192 and aa 237-296) domains leading to activation of downstream molecules involved in growth, differentiation, cell adhesion and migration. Alternate splicing generates an additional isoform that lacks aa 205-304.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.