CRELD1 Antibody (842314) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: B/N
• Clone: 842314
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

CRELD1 Antibody (842314) [Alexa Fluor® 750] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human CRELD-1
  Gln30-Glu362
  Accession # Q96HD1
• Specificity: Detects human CRELD-1 in ELISA.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Neutralization

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CRELD1 Antibody (842314) [Alexa Fluor® 750]

• atrioventricular septal defect 2
• AVSD2
• CIRRIN
• CRELD1
• cysteine-rich with EGF-like domain protein 1
• cysteine-rich with EGF-like domains 1
• DKFZp566D213

Background

CRELD1, also known as cirrin, is an integral membrane protein that functions as a cell adhesion molecule. It is synthesized as a 420 amino acid (aa) precursor with an N-terminal signal peptide, a large extracellular domain with two EGF-like repeats, 2 transmembrane domains separated by a very short cytoplasmic loop, and a short extracellular C-terminal domain. An alternatively spliced isoform with a unique C-terminus that lacks the transmembrane domains has also been cloned. Missense mutations in CRELD1 have been associated with atrioventricular septal defects. The N-terminal extracellular domain of human and mouse CRELD1 share 92% aa sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.