CREB [p Ser121] Antibody


Biological Strategies: Western Blot: CREB [p Ser121] Antibody [NB100-410] - Detection of phospho-CREB in human HEK 293T cells. Top panel: probed with NB 100-410. Bottom panel: probed with CREB antibody. Lanes 2 more

Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, IP
0.3 mg/ml
Validated by:

Biological Strategies


CREB [p Ser121] Antibody Summary

A phospho-peptide spanning the Ser121 phosphorylation site of human CREB. [UniProt# P16220]
p Ser121
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 1:500
  • Immunoprecipitation 0.5 ug
CREB Lysate (NBL1-09461)
Read Publications using
NB100-410 in the following applications:

  • WB
    3 publications

Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
Tris, 50% Glycerol
0.05% Sodium Azide
0.3 mg/ml
Immunogen affinity purified

Alternate Names for CREB [p Ser121] Antibody

  • active transcription factor CREB
  • cAMP responsive element binding protein 1
  • cAMP-response element-binding protein-1
  • cAMP-responsive element-binding protein 1
  • CREB
  • CREB1
  • CREB-1
  • cyclic AMP-responsive element-binding protein 1
  • MGC9284
  • pCREB
  • transactivator protein


CREB (cyclic-AMP response element binding) belongs to bZIP family of transcription factors which acts as a conduit between upstream signalling kinases and downstream target-gene transcription. Following Ser 133 phosphorylation mediated activation; CREB dimerizes for binding to CRE motifs on promoters containing consensus sequence TGACGTCA and together with its anchoring binding partner CBP, pCREB up-regulates transcription of target genes. CREB mediated transcription activation is also enhanced by transducers of regulated CREB (TORC) coactivators which act independently of Ser-133 phosphorylation. CREB's target genes include its family members (CREM, ICER and ATF) and these paralogs/homologs of CREB bind CRE elements to modulate the transcription of particular genes and CREB transcriptional regulation is involved in cell survival, plasticity, learning/memory paradigms, synchronization of circadian rhythmicity and adipose cells differentiation. Over-expression of CREB in transgenic animals can impart oncogenic properties on cells in various tissues and that aberrant CREB expression is associated with human malignancies. Moreover, defects in CREB1 have been linked to angiomatoid fibrous histiocytoma (AFH).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CREB Antibody (NB100-410)(8)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

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Showing Publications 1 - 8 of 8.
Publications using NB100-410 Applications Species
Steven A, Leisz S, Sychra K et al. Hypoxia-mediated alterations and their role in the HER-2/neuregulated CREB status and localization Oncotarget Aug 9 2016 [PMID: 27409833] (WB, Human) WB Human
Byrd PJ, Stewart GS, Smith A et al. A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development. PLoS Genet 2016 Mar [PMID: 26990772] (WB) WB
Byrd PJ, Srinivasan V, Last JI et al. Severe reaction to radiotherapy for breast cancer as the presenting feature of ataxia telangiectasia. Br J Cancer. 2011 Dec 6. [PMID: 22146522]
Shi Y et al. Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies. J Biol Chem;282 (12):9236-43. 2007 Mar 23. [PMID: 17244605]
Shanware NP et al. Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage. J Biol Chem;282(9):6283-91. 2007 Mar 2. [PMID: 17209043]
Dodson GE, Tibbetts RS. DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. J Biol Chem;281(3):1692-7. 2006 Jan 20. [PMID: 16293623] (WB, Human) WB Human
Shi Y et al. Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo. J Biol Chem;280(48):40195-200. 2005 Dec 2. [PMID: 16221684]
Shi Y et al. Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress. Proc Natl Acad Sci U S A;101(16):5898-903. 2004 Apr 20. [PMID: 15073328]

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for CREB Antibody (NB100-410). (Showing 1 - 1 of 1 FAQs).

  1. May I know which creb1 antibody is good for ChIP? I found a paper using your rabbit polyclonal creb1 antibody for ChIP but they didn't indicate the catalog number.
    • We are not aware of any of our Creb1 antibodies being used in ChIP at this time. If you can provide us with the PMID of the paper you are referring to I can contact the author. Otherwise, you can use our Innovators Reward Program to try an antibody in a novel species and application.

Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB100-410AF405
Alexa Fluor 488 Labeled NB100-410AF488
Alexa Fluor 647 Labeled NB100-410AF647
Alexa Fluor 700 Labeled NB100-410AF700
Biotin Labeled NB100-410B
DyLight 405 Labeled NB100-410V
DyLight 488 Labeled NB100-410G
DyLight 550 Labeled NB100-410R
DyLight 650 Labeled NB100-410C
HRP Labeled NB100-410H

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Bioinformatics Tool for CREB Antibody (NB100-410)

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Blogs on CREB.

Exploring the Many Roles of PGC-1 alpha
The peroxisome proliferator-activated receptor gamma, co-activator 1 (PGC-1 alpha or PPARGC1A) gene encodes a 91 kDa nuclear protein that acts as a transcriptional co-activator involved in energy metabolism. Interaction with PPAR gamma allows it to in...  Read full blog post.

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Gene Symbol CREB1