CREB [p Ser121] Antibody


Western Blot: CREB [p Ser121] Antibody [NB100-410] - Detection of phospho-CREB in human HEK 293T cells. Top panel: probed with NB 100-410. Bottom panel: probed with CREB antibody. Lanes 2 and 4 treated with lambda more

Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, IP
0.3 mg/ml

CREB [p Ser121] Antibody Summary

A phospho-peptide spanning the Ser121 phosphorylation site of human CREB [UniProt# P16220]
p Ser121
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
Tris 50% glycerol
0.05% Sodium Azide
0.3 mg/ml
Immunogen affinity purified


  • Western Blot 1:500
  • Immunoprecipitation 0.5 ug
Application Notes
This CREB [p Ser121] antibody is useful for Immunoprecipitation and Western blot.
Read Publications using
NB100-410 in the following applications:

  • WB
    1 publication

Alternate Names for CREB [p Ser121] Antibody

  • active transcription factor CREB
  • cAMP responsive element binding protein 1
  • cAMP-response element-binding protein-1
  • cAMP-responsive element-binding protein 1
  • CREB
  • CREB1
  • CREB-1
  • cyclic AMP-responsive element-binding protein 1
  • MGC9284
  • transactivator protein


CREB (cyclic-AMP response element binding) belongs to bZIP family of transcription factors which acts as a conduit between upstream signalling kinases and downstream target-gene transcription. Following Ser 133 phosphorylation mediated activation; CREB dimerizes for binding to CRE motifs on promoters containing consensus sequence TGACGTCA and together with its anchoring binding partner CBP, pCREB up-regulates transcription of target genes. CREB mediated transcription activation is also enhanced by transducers of regulated CREB (TORC) coactivators which act independently of Ser-133 phosphorylation. CREB's target genes include its family members (CREM, ICER and ATF) and these paralogs/homologs of CREB bind CRE elements to modulate the transcription of particular genes and CREB transcriptional regulation is involved in cell survival, plasticity, learning/memory paradigms, synchronization of circadian rhythmicity and adipose cells differentiation. Over-expression of CREB in transgenic animals can impart oncogenic properties on cells in various tissues and that aberrant CREB expression is associated with human malignancies. Moreover, defects in CREB1 have been linked to angiomatoid fibrous histiocytoma (AFH).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CREB Antibody (NB100-410)(6)

Reviews for CREB Antibody (NB100-410) (0)

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for CREB Antibody (NB100-410). (Showing 1 - 1 of 1 FAQs).

  1. May I know which creb1 antibody is good for ChIP? I found a paper using your rabbit polyclonal creb1 antibody for ChIP but they didn't indicate the catalog number.
    • We are not aware of any of our Creb1 antibodies being used in ChIP at this time. If you can provide us with the PMID of the paper you are referring to I can contact the author. Otherwise, you can use our Innovators Reward Program to try an antibody in a novel species and application.

Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB100-410AF405
Alexa Fluor (R) 488 Labeled NB100-410AF488
Alexa Fluor (R) 647 Labeled NB100-410AF647
Alexa Fluor (R) 700 Labeled NB100-410AF700
Biotin Labeled NB100-410B
DyLight 405 Labeled NB100-410V
DyLight 488 Labeled NB100-410G
DyLight 550 Labeled NB100-410R
DyLight 650 Labeled NB100-410C
FITC Labeled NB100-410F
HRP Labeled NB100-410H

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Blogs on CREB.

Exploring the Many Roles of PGC-1 alpha
The peroxisome proliferator-activated receptor gamma, co-activator 1 (PGC-1 alpha or PPARGC1A) gene encodes a 91 kDa nuclear protein that acts as a transcriptional co-activator involved in energy metabolism. Interaction with PPAR gamma allows it to in...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol CREB1

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