COX-2 Antibody

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ELISA: COX-2 Antibody [23240002]

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

COX-2 Antibody Summary

Immunogen
This antibody is specific for the C Terminus Region of the target protein.
Specificity
This product is specific for Human PTGS2.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTGS2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:5000-1:20000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:250-1:2000
Application Notes
This antibody is useful in ELISA, Western Blot and Immunohistochemistry-Paraffin. Use in Mouse reported in customer review.
Control
COX-2 Lysate (NBP2-66242)
Reviewed Applications
Read 1 Review rated 5
using
23240002 in the following applications:

Publications
Read Publications using 23240002.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
Preservative
No Preservative
Purity
Immunogen affinity purified

Notes

Manufactured by SDIX's proprietary Genomic Antibody Technology™. GAT FAQs.

Alternate Names for COX-2 Antibody

  • COX2
  • COX-2
  • COX2cyclooxygenase 2b
  • cyclooxygenase-2
  • EC 1.14.99
  • EC 1.14.99.1
  • GRIPGHS
  • hCox-2
  • PGG/HS
  • PGH synthase 2
  • PGHS-2
  • PHS II
  • PHS-2
  • PHS-II
  • prostaglandin G/H synthase 2
  • prostaglandin G/H synthase and cyclooxygenase
  • Prostaglandin H2 synthase 2
  • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase andcyclooxygenase)
  • Prostaglandin-endoperoxide synthase 2
  • PTGS2

Background

COX2 (Cyclooxygenase-2. PGHS2) is an inducible dimeric enzyme belonging to prostaglandin G/H synthase family. COX2, similar to COX1, functions to form prostaglandins by catalyzing the synthesis of cyclic endoperoxides from arachidonic acid. COX2 expression is induced by lipopolysaccaride (LPS) and peptoglycan (PGN) and is highly expressed in activated marcophages. It has been implicated as a mediator of inflammation and a possible role in prostanoid signaling in activity-dependent plasticity (1). COX2 is considered as an ideal marker in immune response regulation studies and a therapeutic target against inflammatory diseases (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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23240002
Species: Hu, Mu
Applications: WB, ELISA, IHC, IHC-P
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Publications for COX-2 Antibody (23240002)(2)

Review for COX-2 Antibody (23240002) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Mouse.

Reviews using 23240002:
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WB
(1)
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(1)
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Images Ratings Applications Species Date Details
 
reviewed by:
Anonymous
WB Mouse 09/08/2010
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Summary

ApplicationWestern Blot
Sample TestedHela whole lysate
SpeciesMouse

Blocking

Blocking DetailsBlocking buffer: Skim milk in PBS-T buffer; Blocking concentration: 5% ; Blocking time: 2 hours; Blocking temp: 25 Celsius

Primary Anitbody

Dilution RatioPrimary antibody dilution: 1:5000; Incubation time: overnight; Incubation temp: 4 Celsius; Incubation buffer: PBS T; Sample amount: 50 ug

Secondary Antibody

Secondary DescriptionInvitrogen, Goat anti rabbit IgG HRP
Secondary Manufacturer Cat#65-6120
Secondary Concentration1:5000

Details

Detection NotesDetection method: Chemiluminescent Western Blotting; Exposure time: 10 sec; Specific bands: 42 kDa kDa;

Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for COX-2 Antibody (23240002) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Additional Array Products

Bioinformatics Tool for COX-2 Antibody (23240002)

Discover related pathways, diseases and genes to COX-2 Antibody (23240002). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for COX-2 Antibody (23240002)

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Pathways for COX-2 Antibody (23240002)

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PTMs for COX-2 Antibody (23240002)

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Research Areas for COX-2 Antibody (23240002)

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Blogs on COX-2.

SUCNR1/GPR91 - a potential role in renovascular hypertension
SUCNR1 is the cognate receptor for the Kreb's citric acid cycle intermediate succinate. It is of interest to scientists because it is involved in not only energy metabolism but possibly also in renovascular hypertension, a condition linked to diabe...  Read full blog post.

Inhibitor kappa B-alpha (IkappaB-alpha)
The transcription factor nuclear factor kappa beta (NFkB) is highly regulated by triggers such as stress, free-radicals, UV light, and hypoxia. NFkB is one of the fastest responding transcription factors in humans. The NFKB signaling pathway is ess...  Read full blog post.

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Recent Reviews

5
5
1
4
0
3
0
2
0
1
0

 
Anonymous
09/08/2010
Application: WB
Species: Mouse

Bioinformatics

Gene Symbol PTGS2
Entrez
Uniprot