COX-2 Antibody (AS73)

Product Discontinued

COX-2 Antibody (AS73) Summary

• Immunogen: Unfortunately, this information is considered to be commercially sensitive
• Localization: Microsomal membrane
• Specificity: COX2 (AS73)
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: PTGS2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000

Reactivity Notes

Cross-reacts with Rat. Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.08% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for COX-2 Antibody (AS73)

• COX2
• COX-2
• COX2cyclooxygenase 2b
• cyclooxygenase-2
• EC 1.14.99
• EC 1.14.99.1
• GRIPGHS
• hCox-2
• PGG/HS
• PGH synthase 2
• PGHS-2
• PHS II
• PHS-2
• PHS-II
• prostaglandin G/H synthase 2
• prostaglandin G/H synthase and cyclooxygenase
• Prostaglandin H2 synthase 2
• prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase andcyclooxygenase)
• Prostaglandin-endoperoxide synthase 2
• PTGS2

Background

COX2 (Cyclooxygenase 2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for COX-2 Antibody (NB600-971)(4)

Publications using NB600-971

• Mohamed K, Abdelfattah M, El-khadragy M et al. Rutin-loaded selenium nanoparticles modulated the redox status, inflammatory, and apoptotic pathways associated with pentylenetetrazole-induced epilepsy in mice Green Processing and Synthesis 2023-01-26 (ELISA, Mouse)
• Alsharif KF, Albrakati A, Al Omairi NE et al. Neuroprotective efficacy of the bacterial metabolite, prodigiosin, against aluminium chloride-induced neurochemical alternations associated with Alzheimer's disease murine model: Involvement of Nrf2/HO-1/NF-kappa B signaling Environmental toxicology 2022-11-29 [PMID: 36447373]
• Al Omairi N, Albrakati A, Alsharif K et al. Selenium Nanoparticles with Prodigiosin Rescue Hippocampal Damage Associated with Epileptic Seizures Induced by Pentylenetetrazole in Rats Biology 2022-02-23 [PMID: 35336729]
• Abdelfattah MS, Elmallah MIY, Ebrahim HY et al. Prodigiosins from a marine sponge-associated actinomycete attenuate HCl/ethanol-induced gastric lesion via antioxidant and anti-inflammatory mechanisms PLoS ONE 2019-06-13 [PMID: 31194753] (ELISA, Rat)

Bioinformatics

• Gene Symbol: PTGS2
• Entrez:
  • 29527(Rat)