Complement Factor I Antibody (271203)

• Reactivity: Hu
• Applications: WB, IP
• Clone: 271203
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

Complement Factor I Antibody (271203) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Complement Factor I
  Lys19-Val583
  Accession # P05156
• Specificity: Detects human Complement Factor I in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CFI
• Purity: Protein A or G purified from hybridoma culture supernatant
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 25 ug/mL
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein A or G purified from hybridoma culture supernatant
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Complement Factor I Antibody (271203)

• AHUS3
• C3b Inactivator
• C3B/C4B inactivator
• C3BINA
• C3b-inactivator
• CFI
• complement component I
• complement control protein factor I
• complement factor I heavy chain
• Complement Factor I
• EC 3.4.21
• EC 3.4.21.45
• FIC3b-INA
• I factor (complement)
• IF
• KAF
• Konglutinogen-activating factor
• light chain of factor I

Background

Factor I is a secreted serine protease present in human plasma. It specifically cleaves and inactivates complement subcomponents C3b, iC3b, and C4b.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Complement Factor I Antibody (MAB3307)(2)

Publications using MAB3307

• SJ Clark, S McHarg, V Tilakaratn, N Brace, PN Bishop Bruch's Membrane Compartmentalizes Complement Regulation in the Eye with Implications for Therapeutic Design in Age-Related Macular Degeneration Front Immunol, 2017;8(0):1778. 2017 [PMID: 29312308] (Western Blot, Human)
• Johnson J, Borisevich V, Rockx B, Parks G A novel factor I activity in Nipah virus inhibits human complement pathways through cleavage of C3b. J Virol, 2015;89(2):989-98. 2015 [PMID: 25355897] (Western Blot, Human)

Bioinformatics

• Gene Symbol: CFI
• Uniprot:
  • P05156()