Complement Component C1s Antibody

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Immunohistochemistry-Paraffin: Complement Component C1s Antibody [NBP1-50300] - Analysis of anti-C1S / Complement C1s antibody staining of human placenta at concentration 5 ug/ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, IHC-P
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Complement Component C1s Antibody Summary

Immunogen
Complement component 1 subunit (C1s) purified from human plasma.
Specificity
Recognizes human C1s.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
C1S
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100 - 1:2000
  • Immunohistochemistry-Paraffin 5 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.4), 0.15M NaCl and 50% Glycerol
Preservative
No Preservative
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Complement Component C1s Antibody

  • basic proline-rich peptide IB-1
  • C1 esterase
  • C1S
  • complement C1s subcomponent
  • Complement component 1 subcomponent s
  • complement component 1, s subcomponent
  • Complement Component C1s
  • EC 3.4.21
  • EC 3.4.21.42
  • FLJ44757

Background

C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes (1) but also by other cells (2,3). The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2 (1,4,5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol C1S
Entrez
Uniprot