Complement Component C1s Antibody

Immunohistochemistry-Paraffin: Complement Component C1s Antibody [NBP1-50300] - Analysis of anti-C1S / Complement C1s antibody staining of human placenta at concentration 5 ug/ml.

Product Discontinued

Complement Component C1s Antibody Summary

• Immunogen: Complement component 1 subunit (C1s) purified from human plasma.
• Specificity: Recognizes human C1s.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: C1S
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100 - 1:2000
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 10mM HEPES (pH 7.4), 0.15M NaCl and 50% Glycerol
• Preservative: No Preservative
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Complement Component C1s Antibody

• basic proline-rich peptide IB-1
• C1 esterase
• C1S
• complement C1s subcomponent
• Complement component 1 subcomponent s
• complement component 1, s subcomponent
• Complement Component C1s
• EC 3.4.21
• EC 3.4.21.42
• FLJ44757

Background

C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes (1) but also by other cells (2,3). The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2 (1,4,5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: C1S
• Entrez:
  • 716(Human)
• Uniprot:
  • P09871()