Complement Component C1rLP Antibody

• Reactivity: Mu
• Applications: WB, IP
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

Complement Component C1rLP Antibody Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Complement Component C1rLP
  Ser18-Asp456
  Accession # AAP41417
• Specificity: Detects mouse Complement Component C1rLP in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 40% cross‑reactivity with recombinant human (rh) C1rLP is observed and less than 1% cross‑reactivity with rhC1R and rhC1S is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: C1RL
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 25 ug/mL
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Complement Component C1rLP Antibody

• C1RL
• C1RL1
• C1RL1complement C1r subcomponent-like protein
• C1r-like protein
• C1r-like serine protease analog protein
• C1r-LPcomplement C1r-like proteinase
• C1RLPEC 3.4.21.-
• CLSPa
• complement component 1, r subcomponent-like
• Complement Component C1rLP
• EC 3.4.21
• EC 3.4.21.41

Background

Mouse C1rLP, also CLSPa, is a 55 kDa, secreted, atypical glycoprotein member of the AGY group of servine proteases. It has protease activity for pro-haptoglobin, but accomplishes cleavage without a typical Asp in the catalytic site. In addition, it is proposed to block unwanted complement-mediated proteolysis. Mature C1rLP is 443 amino acids (aa) in length. It contains one CUB domain (aa 43‑165), a truncated CCP2 region (aa 167‑223) and a serine protease domain (aa 239‑482). There is a potential short form that utilizes an alternate start site at Met 27. Over aa 44‑456, mouse C1rLP is 78% and 90% aa identical to human and rat C1rLP, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Complement Component C1rLP Antibody (AF3990)(1)

Publication using AF3990

• Gaultier A, Arandjelovic S, Niessen S, Overton CD, Linton MF, Fazio S, Campana WM, Cravatt BF, Gonias SL Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood, 2008-03-27;111(11):5316-25. 2008-03-27 [PMID: 18369152] (Western Blot, Mouse)

Bioinformatics

• Gene Symbol: C1RL
• Uniprot:
  • AAP41417()